In a medium saucepan, melt the butter over medium heat.
Add the flour and stir to combine. Cook for 1 minute.
Whisk in the milk and bring to a simmer. Add the garlic powder, onion powder, black pepper, and salt. Stir until thickened, about 3 minutes.
Add the cheddar, mozzarella, and parmesan cheeses and stir until melted and combined, about 5 minutes.
Add the elbow macaroni and stir until combined. Cover the pot and reduce the heat to low. Simmer for 10 minutes, stirring occasionally.
Uncover the pot and stir in the panko breadcrumbs. Cook for 5 minutes, stirring occasionally.
Serve hot and enjoy!